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Amino Z Agmatine
The last decade has seen the supplement industry come along in leaps and bounds.
As a result, there has been a huge increase in the amount of research conducted that has unearthed a myriad of new compounds -- compounds that just might have the potential to improve the results of your training.
And while many of them may not be worth your time, Agmatine is.
What is Agmatine?
So, what in the world is Agmatine?
In short, it is a unique compound made within your body from the specific amino acid “L-arginine” (which is obtained through diet).
Agmatine most commonly acts as a neurotransmitter within the neurons spread throughout your body. However, recent research has indicated that it might also play a role within some of the key cells of your muscle tissue.
As a result, its supplementation may have implications for mental and physical performance.
How does Agmatine work?
I want to highlight the fact that while Agmatine has been the topic of discussion amongst researchers across the globe, we still don't have a full understanding of how it works in every possible manner.
With the reason being that it is all very complex.
Agmatine plays a role in a number of different cells spread throughout your entire body. As such, it interacts with many of those cells in a number of different ways. But one thing we have established is that this unique compound plays a key role blocking the production of “nitric oxide synthase” (or NOS for short):
Now, there are three types of compounds found within your body that produce nitric oxide -- being iNOS, nNOS, and eNOS:
• iNOS produces large amounts of nitric oxide to help the immune system kill harmful bacteria.
• nNOS stimulates nitric oxide production by interacting with cells within your brain.
• eNOS stimulates nitric oxide production within your cells,increasing blood flow and enhancing the transportation of oxygen and nutrients around your body.
Some research has shown that agmatine can regulate nitric oxide levels by inhibiting iNOS and nNOS, while simultaneously increasing eNOS -- which could explain its impact on athletic performance.
In conjunction with its effects on nitric oxide production, it also appears to interact with several receptors within the brain that have a number of functions related to the control of mood and emotional wellbeing.
And this is where it derives its mental benefits.
OK, so we now have an understanding of how Agmatine works in your body -- but what are the benefits of supplementing with additional Agmatine?
Well, despite the research being in its infancy, there appears to be a couple of big ones.
1. Agmatine and Mental Health
Given the unique role that Agmatine plays in the brain, it should come as no surprise that it may have some applications within the realm of mental health -- which is exactly what the research suggests.
By interacting with a number of receptors in the brain, Agmatine has been shown to contribute to reductions in symptoms of depression and anxiety, while simultaneously causing large increases in mood and emotional wellbeing.
In fact, a small study conducted in three patients with diagnosed depression demonstrated that agmatine supplementation can completely eliminate depressive symptoms when taken in doses of 2-3mg per day .
Now, you might be wondering what this means for you and your training, and I would like to think quite a lot.
When it comes to making long term progress, one of the most important things you need to address is recovery -- and something that has been shown to impact recovery is stress, and its associated feelings of depression and anxiety.
With this in mind, Agmatine might play an important role by enhancing recovery, while making you feel happier and more excited for training in the process.
This is a huge win-win.
2. Agmatine, Testosterone, and Muscle Growth
Some interesting animal-based studies have shown that agmatine supplements can increase the production of luteinizing hormone -- which in turn, directly increases testosterone levels throughout the body.
As a result, agmatine can create a hormonal environment that optimises muscle growth .
While more research is needed in humans to demonstrate this with greater certainty, early research would indicate that agmatine could offer an effective way to improve the results of your training.
3. Agmatine and Fat Loss
Finally, there is also some interesting animal based research demonstrating that supplementing with Agmatine can cause a significant increase in the mobilisation and breakdown of fat for energy.
Over time this can lead to a substantial amount of fat loss .
Again, more research in humans is needed, but these promising early signs would suggest that Agmatine could offer a valuable addition to your supplement regime irrespective of whether you are bulking or cutting.
Agmatine Dosage and Side effects
Because the research on agmatine is so new, we do not have a clear idea as to what the optimal dosage is -- however, research thus far has indicated that taking between 1 and 3 grams per day is enough to get a potent effect without any major side effects.
However, we should also note that some research has reported minor side effects in a very small portion of individuals, including nausea, diarrhea, and an upset stomach.
These would all indicate a valid reason to reduce your dosage during a period of supplementation.
Agmatine is an interesting new compound that shows a lot of promise when it comes to improving mental health and emotional wellbeing, boosting muscle growth, and even accelerating fat loss.
However, because it is so new, we would encourage you to seek advice from your medical professional before commencing supplementation.
1. Shopsin, Baron. "The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study." Acta neuropsychiatrica 25.2 (2013): 113-118.
2. Kalra, Satya P., et al. "Agmatine, a novel hypothalamic amine, stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizing hormone-releasing hormone release in vitro." Neuroscience letters 194.3 (1995): 165-168.
3. Nissim, Itzhak, et al. "The molecular and metabolic influence of long term agmatine consumption." Journal of Biological Chemistry 289.14 (2014): 9710-9729.
Total Serves per Package: 2000
Serving Size: 0.5000g
|Per 0.5g Serve||Per 100g|
|Energy||8.5 kJ||1700 kJ|
|Protein||0.5 g||100 g|
|Carbohydrate||0 g||0 g|
|Complex Carbs||0 g||0 g|
|Sugar||0 g||0 g|
|Fibre||0 g||0 g|
|Fat||0 g||0 g|
|Saturated Fat||0 g||0 g|
|Caffeine||0 mg||0 mg|
|Sodium||0 mg||0 mg|
Mix 1 serve with 250mL of water and mix well with a shaker.
Please note that the nutritional profile will vary according to your flavour selection.
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